Depression is a crippling disease, and many people need to turn to antidepressants in order to regain control of their lives. Antidepressants are among the most commonly prescribed medication in the United States, and they are often prescribed for long-term use. Data on long-term effects is limited, but some studies have found that long-term use can cause blood sugar problems, weight gain, and addiction to the drug. Some people also report that long-term use causes them not to feel like themselves. Are the side effects of these drugs worth it? Is quality of life actually improving? What are the other options for treatment when it comes people living with severe depression?